ODCs

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1 OMIM reference -
1 associated gene
No signs/symptoms info

PROTEIN INTERACTIONS: 1

2 associated genes
19 signs/symptoms

Pyruvate dehydrogenase E3-binding protein deficiency

Desmoplastic small round cell tumor

PDHX	(UniProt - OMIM)		EWSR1	(UniProt - OMIM)
			WT1	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	PDHX	(0.73)	EWSR1

Citations in the biomedical literature:

Pyruvate dehydrogenase E3-binding protein deficiency		Desmoplastic small round cell tumor
	Synonym(s): - 2-oxoglutarate complex deficiency - Branched chain alpha-ketoacid dehydrogenase complex deficiency - Diaphorase deficiency - Dihydrolipoyl dehydrogenase deficiency - Glycine cleavage system L protein deficiency - Lipoamide dehydrogenase deficiency - Pyruvate dehydrogenase complex component E3 deficiency - Pyruvate dehydrogenase protein X component deficiency		Synonym(s): - DSRCT

	Classification (Orphanet): - Inborn errors of metabolism - Rare developmental defect during embryogenesis - Rare genetic disease - Rare neurologic disease		Classification (Orphanet): - Rare abdominal surgical disease - Rare oncologic disease

	Classification (ICD10): - Endocrine, nutritional and metabolic diseases -		Classification (ICD10): - Neoplasms -

	Epidemiological data: Class of prevalence: unknown Average age onset: neonatal/infancy Average age of death: child / adolescent Type of inheritance: autosomal recessive		Epidemiological data: Class of prevalence: unknown Average age onset: adolescence / young Average age of death: - Type of inheritance: sporadic

	External references: 1 OMIM reference - No MeSH references		External references: No OMIM references 1 MeSH reference: D058405

Desmoplastic small round cell tumor
	Very frequent - Acute abdominal pain / colic - Digestive neoplasm / tumor / carcinoma / cancer - Lymphadenopathy / polyadenopathies - Peritoneal diseases - Soft tissue sarcoma / cancer / tumor / liposarcoma / myosarcoma Frequent - Hepatomegaly / liver enlargement (excluding storage disease) - Intestinal obstruction / ileus - Mediastinal / hilar adenopathies - Nausea / vomiting / regurgitation / merycism / hyperemesis - Weight loss / loss of appetite / break in weight curve / general health alteration Occasional - Anaemia - Ascitis - Central nervous system / peripheral nerves neoplasm / tumor / carcinoma / cancer - Lung / bronchopulmonary neoplasm / tumor / carcinoma / cancer - Nose / nasal sinus neoplasm / tumor / carcinoma / cancer - Ovary / Fallopian tube neoplasm / tumor / carcinoma / cancer (excl. teratoma / germinoma) - Pancreatic / pancreas neoplasm / tumor / carcinoma / cancer - Testis anomalies - Wasted (excluding lipodystrophy) / poorly muscled build / cachexy
Pyruvate dehydrogenase E3-binding protein deficiency
(no data available)